Tottenham make two changes for the game at Old Trafford, with Mousa Dembele and Danny Rose coming in for Davinson Sanchez and Ben Davies.
Goalkeeper Hugo Lloris, recently charged with drink-driving, plays for the visitors.
United make six changes in the wake of their 3-2 defeat at Brighton.
Eric Bailly, Juan Mata, Anthony Martial and Andreas Pereira, who all started that game, are not even in their matchday squad this time.
Victor Lindelof and Eric Bailly are replaced by Phil Jones and Chris Smalling in defence.
Marcus Rashford is dropped to the bench and there are starting places for Antonio Valencia, Nemanja Matic and Ander Herrera as well as Jesse Lingard.
Man Utd: De Gea, Valencia, Shaw, Jones, Smalling, Matic, Fred, Herrera, Pogba, Lingard, Lukaku.
Subs: Grant, Lindelof, Young, Fellaini, McTominay, Sanchez, Rashford.
Tottenham: Lloris, Trippier, Rose, Alderweireld, Vertonghen, Dier, Dembele, Alli, Eriksen, Moura, Kane.
Subs: Vorm, Davies, Sanchez, Aurier, Winks, Lamela, Llorente.