Harry Winks starts for Spurs in their Champions League clash in Germany.
Spurs, 3-0 up from the first leg, have Eric Dier among their substitutes.
Winks, who has had a hip injury, replaces Victor Wanyama.
The midfielder was passed fit to return to the squad, as was Dier, who has recovered from tonsillitis.
Serge Aurier also starts, with Kieran Trippier having been rested. Trippier did not travel with the squad.
Spurs make three changes in total from the north London derby against Arsenal – the other is Ben Davies in for Danny Rose.
Tottenham: Lloris, Aurier, Alderweireld, Sanchez, Vertonghen, Davies, Winks, Sissoko, Eriksen, Son, Kane.
Subs: Gazzaniga, Rose, Dier, Wanyama, Lamela, Lucas, Llorente.
Dortmund: Burki, Wolf, Akanji, Weigl, Diallo, Witsel, Guerreiro, Gotze, Sancho, Reus, Alcacer.