Eric Dier looks set to replace the injured Toby Alderweireld at centre-back for Tottenham’s Champions League game at Bayer Leverkusen on Tuesday.
Alderweireld was stretchered off during the 1-1 draw with West Bromwich Albion at the weekend and will undergo scans to determine the extent of his knee injury.
Dier stepped in alongside Jan Vertonghen for the final half an hour at The Hawthorns and is expected to continue in the role in Germany.
Having been rested against West Brom, Danny Rose is set to return to the starting line-up, replacing Ben Davies. Son Hueng-min is likely to play against his former club.
Harry Kane, who has not played since injuring ankle ligaments against Sunderland on 18 September, was due to return to training on Monday but will need time to build up his sharpness.
Tottenham will be aiming for only their second win on German soil in 42 years – coincidentally, their only other win came at Leverkusen in the group stages of the Uefa Cup in 2006, when Dimitar Berbatov got the winner.
Spurs won their previous Champions League match at CSKA Moscow 1-0, while Leverkusen – who sit 10th in the Bundesliga – were denied victory at Monaco by an injury-time goal.