Tottenham welcome back Eric Dier, who has recovered from a hamstring injury.
Spurs make four changes from last Sunday’s Premier League draw with West Ham.
Matt Doherty, Lucas Moura and Ben Davies come in along with Dier. Gareth Bale is on the bench again.
Burnley, meanwhile, make one change, with Matt Lowton replacing Erik Pieters at right-back.
Burnley: Pope, Lowton, Long, Tarkowski, Taylor, Gudmundsson, Brownhill, Westwood, McNeil, Barnes, Wood.
Subs: Peacock-Farrell, Dunne, Benson, Stephens, Brady, Rodriguez, Vydra.
Tottenham: Lloris, Doherty, Alderweireld, Dier, Davies, Sissoko, Hojbjerg, Ndombele, Moura, Son, Kane.
Subs: Hart, Reguilon, Rodon, Lo Celso, Lamela, Bale, Vinicius.