Kyle Walker and Mousa Dembele return to the Tottenham side for the Europa League last-32 second leg at Wembley along with keeper Hugo Lloris.
Kieran Trippier and Harry Winks, who started Sunday’s FA Cup win at Fulham, drop to the bench.
Toby Alderweireld, Eric Dier and Jan Vertonghen also all start, with boss Mauricio Pochettino appearing to have returned to a 3-4-2-1 formation.
Spurs, 1-0 down from the first leg, have never lost at home to a Belgian side.
Tottenham: Lloris, Walker, Dier, Alderweireld, Vertonghen, Davies, Wanyama, Dembele, Eriksen, Dele, Kane.
Subs: Vorm, Wimmer, Trippier, Winks, Sissoko, Son, Janssen.