Youngster Ashley Fletcher comes into the West Ham side to face his former club in tonight’s EFL Cup quarter-final at Old Trafford.
The Hammers make five changes from the side which drew 1-1 against United in the league on Sunday.
Winston Reid is back after suspension and there are also recalls for Edimilson Fernandes, Sofiane Feghouli and keeper Adrian.
United also make five changes, including recalls for Wayne Rooney and former West Ham man Michael Carrick.
Man Utd: De Gea; Valencia, Jones, Rojo, Shaw; Herrera; Carrick; Mkhitaryan, Rooney, Martial, Ibrahimovic.
Subs: Romero, Blind, Schneiderlin, Schweinsteiger, Lingard, Mata, Rashford.
West Ham: Adrian; Reid, Kouyate, Ogbonna; Antonio, Obiang, Fernandes, Cresswell; Feghouli, Fletcher, Payet.
Subs: Randolph, Nordtveit, Lanzini, Zaza, Noble, Collins, Masuaku.