Toby Alderweireld starts his first Premier League game in almost two months as Tottenham make two changes for their trip to Manchester United.
Centre-back Alderweireld injured his knee against West Brom on 15 October but made his return as a substitute against CSKA Moscow in midweek.
He replaces Eric Dier in the starting line-up, with Mousa Dembele coming in for Harry Winks.
Winger Erik Lamela and striker Vincent Janssen remain unavailable.
Manchester United revert to the same XI that drew with Everton in their last Premier League game
It means returns for Antonio Valencia and former Tottenham midfielder Michael Carrick, after both were rested for the Europa League game against Zorya Luhansk.
Defender Eric Bailly, like Alderweireld, returned from injury in midweek but is only on the bench, alongside Wayne Rooney, Juan Mata and Marcus Rashford.
Man Utd: De Gea; Valencia, Jones, Rojo, Darmian; Herrera, Carrick; Mkhitaryan, Pogba, Martial; Ibrahmiovic.
Subs: Romero, Bailly, Blind, Fellaini, Mata, Rooney, Rashford.
Tottenham: Lloris; Walker, Alderweireld, Vertonghen, Rose; Wanyama, Dembele; Eriksen, Alli, Son; Kane.
Subs: Vorm, Wimmer, Davies, Dier, Winks, Sissoko, Nkoudou.