Arsenal are without Laurent Koscielny, who misses out after suffering a recurrence of a calf problem.
Alex Oxlade-Chamberlain remains sidelined with a hamstring injury, but Alexis Sanchez has been passed fit to play despite picking up a knock against Stoke.
The Gunners need to win tonight’s game at the Emirates Stadium in order to preserve their slim chance of securing a top-four finish.
Relegated Sunderland make two changes, with the fit-again Lee Cattermole returning to their starting line-up.
Arsenal: Cech, Holding, Mustafi, Monreal, Bellerin, Xhaka, Ramsey, Gibbs, Ozil, Sanchez, Giroud.
Subs: Ospina, Gabriel, Elneny, Coquelin, Iwobi, Walcott, Welbeck.
Sunderland: Pickford, Jones, Manquillo, O’Shea, Kone, Oviedo, Ndong, Larsson, Cattermole, Borini, Defoe.
Subs: Mannone, Love, Januzaj, Lescott, Gooch, Gibson, Rodwell.