Moussa Sissoko misses out for Tottenham at Selhurst Park.
Spurs were hoping the midfielder, who has been nursing a knee injury, would pass a fitness test ahead of the FA Cup fourth-round tie.
Fernando Llorente again leads the attack for Spurs, who are without the likes of Harry Kane and Dele Alli and have made seven changes from the Carabao Cup defeat at Chelsea.
Crystal Palace’s new keeper Lucas Perri is on the bench.
The Eagles also make changes, with Connor Wickham up front.
Crystal Palace: Speroni, Ward, Kelly, Sann, Van Aanholt, Meyer, Kouyate, Schlupp, Townsend, Zaha, Wickham.
Subs: Tupper, Wan-Bissaka, Sakho, Riedewald, Milivojevic, Benteke, Ayew.
Tottenham: Gazzaniga, Trippier, Sanchez, Foyth, Vertonghen, Walker-Peters, Dier, Skipp, Nkoudou, Lucas, Llorente.
Subs: Lloris, Aurier, Rose, Wanyama, Winks, Lamela, Sterling.