Crystal Palace defenders Martin Kelly and Jeffrey Schlupp start after both being passed fit following injuries.
Kelly had a hamstring injury and Schlupp an ankle problem but they returned to training last week.
Wilfried Zaha remains sidelined with a knee injury. Palace have lost all eight of the Premier League games he has missed this season and have managed to score just once without him.
Manchester United, meanwhile, are without a number of players, with Ander Herrera, Daley Blind, Phil Jones and Marcos Rojo among those injured.
The visitors make one change, with Jesse Lingard coming in for Anthony Martial.
Crystal Palace: Hennessey, Van Aanholt, Tomkins, Kelly, Wan-Bissaka, Milivojevic, McArthur, Schlupp, Townsend, Sorloth, Benteke.
Subs: Cavalieri, Lee, Souare, Delaney, Rakip, Jach, Riedewald.
Manchester United: De Gea, Young, Lindelof, Smalling, Valencia, Matic, McTominay, Pogba, Lingard, Sanchez, Lukaku.
Subs: Pereira, Bailly, Mata, Carrick, Rashford, Shaw, Darmian.