Both players have been nursing hip injuries and were assessed ahead of the match at Wembley, where Spurs will again be without Dele Alli and Eric Dier. Victor Wanyama starts for the first time since November.
Laurent Koscielny has shaken off a knee injury he suffered late on against Bournemouth and starts for Arsenal.
But boss Unai Emery has surprisingly made five changes from the Bournemouth game, dropping Mesut Ozil and top goalscorer Pierre-Emerick Aubameyang to the bench.
Tottenham: Lloris, Trippier, Alderweireld, Sanchez, Vertonghen, Rose, Wanyama, Sissoko, Eriksen, Son, Kane.
Subs: Gazzaniga, Aurier, Davies, Skipp, Lamela, Moura, Llorente.
Arsenal: Leno, Sokratis, Mustafi, Koscielny, Monreal, Guendouzi, Xhaka, Ramsey, Mkhitaryan, Iwobi, Lacazette.
Subs: Cech, Maitland-Niles, Kolasinac, Torreira, Suarez, Ozil, Aubameyang.