Arsenal’s new signings Nicolas Pepe, David Luiz and Dani Ceballos are all among their substitutes for the game at St James’ Park.
Meanwhile, Newcastle’s record signing, £40million striker Joelinton, starts for the hosts.
Newcastle: Dubravka, Manquillo, Scar, Lascelles, Dummett, Ritchie, Shelvey, Hayden, Longstaff, Almiron, Joelinton.
Subs: Darlow, Clark, Saint-Maximin, Muto, Willems, Krafth, Fernandez.
Arsenal: Leno, Maitland-Niles, Chambers, Sokratis, Monreal, Guendouzi, Xhaka, Willock, Mkhitaryan, Nelson, Aubamyenag.
Subs: Martinez, Ceballos, Lacazette, Torreira, Pepe, Luiz, Martinelli.