Arsene Wenger has named a surprising Arsenal line-up for the game at Old Trafford.
The Gunners boss has made eight changes ahead of Thursday’s Europa League semi-final, with Reiss Nelson and Konstantinos Mavropanos among those starting.
Defender Jordi Osei-Tutu, 19, who has yet to make a first-team appearance, is among Arsenal’s substitutes.
Manchester United, meanwhile, make just one change from the side which beat Tottenham in the FA Cup last weekend. Victor Lindelof is in for Phil Jones.
Manchester United: De Gea, Valencia, Lindelof, Smalling, Young, Herrera, Matic, Pogba, Lingard, Sanchez, Lukaku.
Subs: Pereira, Rojo, Mata, Martial, Rashford, Fellaini, McTominay.
Arsenal: Opsina, Bellerin, Chambers, Mavropanos, Kolasinac, Xhaka, Maitland-Niles, Nelson, Iwobi, Mkhitaryan, Aubameyang.
Subs: Cech, Holding, Monreal, Welbeck, Nketiah, Oseu-Tutu, Willock.