Arsenal appear set to play with a back four as well as no out and out striker at the Etihad Stadium, where Alexandre Lacazette is on the bench.
Alexis Sanchez will lead the Gunners’ attack, while Sead Kolasinac has been passed fit following a hip problem. Alex Iwobi and Francis Coquelin also start.
For Manchester City, David Silva and Kyle Walker return, with Gabriel Jesus again among the substitutes.
Manchester City: Ederson, Walker, Stones, Otamendi, Delph, Fernandinho, Silva, De Bruyne, Sane, Sterling, Aguero.
Subs: Bravo, Danilo, Gundogan, Mangala, Toure, Bernando, Jesus.
Arsenal: Cech, Bellerin, Koscielny, Monreal, Kolasinac, Ramsey, Coquelin, Xhaka, Ozil, Iwobi, Sanchez.
Subs: Macey, Debuchy, Elneny, Wilshere, Walcott, Lacazette, Giroud.