Arsenal, leading 4-1 from the first leg, named a strong side for the Europa League quarter-final clash in Moscow after resting players against Southampton at the weekend.
The Gunners make seven changes in total, with Mesut Ozil, Aaron Ramsey and Alexandre Lacazette among those starting.
Midfielder Granit Xhaka has not travelled to Russia because he is suffering from flu. David Ospina and Henrikh Mkhitaryan are out injured, while Pierre-Emerick Aubameyang is cup-tied.
Mohamed Elneny and Danny Welbeck in for Xhaka and Mkhitaryan are Arsenal’s only changes from the first leg.
CSKA make three changes from the first leg, with Russia Under-21 striker Fyodor Chalov replacing Pontus Wernbloom up front.
Wide-man Kirill Nababkin is back from suspension and there is also a recall for midfielder Kristijan Bistrovic.
CSKA Moscow: Akinfeev, A. Berezutski, Ignashevich, V. Berezutski, Nababkin, Bistrovich, Kuchaev, Dzagoev, Golovin, Musa, Chalov.
Subs: Pomazun, Milanov, Vitinho, Shchennikov, Matcho, Zhamaletdinov, Khosonov.
Arsenal: Cech, Bellerin, Monreal, Mustafi, Koscielny, Elneny, Wilshere, Ramsey, Welbeck, Ozil, Lacazette.
Subs: Macey, Mertesacker, Kolasinac, Holding, Chambers, Nketiah, Iwobi.