Calum Chambers has been brought into the Arsenal side for his first Premier League start of the year.
Gunners boss Mikel Arteta has made five changes from the win over Leicester, with Thomas Partey, Martin Odegaard, Pierre Emerick-Aubameyang and Bukayo Saka also coming in.
Burnley are without Ashley Barnes but Johann Berg Gudmundsson has been passed fit after injury and starts for the Clarets.
Burnley: Pope, Lowton, Tarkowski, Mee, Taylor, Brownhill, Westwood, Gudmundsson, McNeil, Vyrda, Wood.
Subs: Peacock-Farrell, Stephens, Rodriguez, Pieters, Bardsley, Long, Dunne, Brady, Benson.
Arsenal: Leno, Chambers, Tierney, Luiz, Mari, Xhaka, Partey, Saka, Odegaard, Willian, Aubameyang.
Subs: Ryan, Bellerin, Gabriel, Ceballos, Pepe, Holding, Lacazette, Eleney, Martinelli.