Bernd Leno was handed his Arsenal debut as head coach Unai Emery made eight changes for the Europa League opener at home to Vorskla Poltava.
The German goalkeeper has yet to feature for the Gunners since joining from Bayer Leverkusen in the summer but replaced Petr Cech in goal.
Lucas Torreira, another new signing, was handed his first start in midfield alongside Mohamed Elneny – who was yet to feature this campaign.
Emery kept Sokratis Papastathopoulos, Nacho Monreal and Pierre-Emerick Aubameyang in the starting line-up from the weekend win at Newcastle.
Arsenal: Leno, Sokratis, Lichtsteiner, Holding, Monreal, Elneny, Mkhitaryan, Torreira, Iwobi, Welbeck, Aubameyang.
Subs: Martinez, Bellerin, Ozil, Guendouzi, Smith-Rowe, Lacazette, Nketiah.
Vorskla: Shust, Perduta, Chesnakov, Dallku, De Souza, Sharpar, Kravchenko, Kobakhidze, Rebenok, Kulach, Kolomoets.
Subs: Tkachenko, Giorgadze, Sakiv, Sklyar, Mysyk, Sergiychuk, Da Cruz.