Dani Ceballos has been passed fit for Arsenal but Willian misses out. Thomas Partey makes his first league start.
The Gunners, already without the injured Rob Holding, hoped Willian would recover from a knock in time to play.
Leicester, meanwhile, hoped Jamie Vardy would be able to return to their starting line-up following a calf problem, but he is among their substitutes.
The visitors make two changes, with James Maddison and Christian Fuchs coming in.
Arsenal: Leno, Luiz, Gabriel, Tierney, Bellerin, Xhaka, Partey, Ceballos, Saka, Lacazette, Aubameyang.
Subs: Runarsson, Mustafi, Maitland-Niles, Elneny, Willock, Pepe, Nketiah.
Leicester: Schmeichel, Fofana, Evans, Fuchs, Castagne, Mendy, Praet, Justin, Tielemans, Barnes, Maddison.
Subs: Ward, Morgan, Under, Choudhury, Albrighton, Iheanacho, Vardy.