Mark Noble has been dropped, Andre Ayew is back in the West Ham squad and on the bench for David Moyes’ first home match in charge, while Andy Carroll keeps his place.
Ayew missed the recent defeat at Watford because of illness. Marko Arnautovic suffered a minor injury in that game but has been passed fit.
Noble is among the substitutes and has been replaced in the starting line-up by Arthur Masuaku, who makes only his third league start of the season.
The Hammers are still without injured trio Javier Hernandez, Michail Antonio and James Collins.
Leicester, meanwhile, are without the injured Robert Huth and Matty James.
West Ham: Hart, Zabaleta, Reid, Ogbonna, Cresswell, Obiang, Kouyate, Arnautovic, Lanzini, Masuaku, Carroll.
Subs: Adrian, Rice, Noble, Quina, Fernandes, Ayew, Sakho.
Leicester: Schmeichel, Simpson, Morgan, Maguire, Fuchs, Mahrez, Ndidi, Albrighton, Iborra, Gray, Vardy.
Subs: Hamer, Chilwell, Dragovic, King, Okazaki, Slimani, Iheanacho.