Mikel Arteta admits injuries to Bukayo Saka and Declan Rice “don’t look good”.
The England internationals were both taken off injured during Sunday’s 1-1 draw with Chelsea.
Rice, who was playing with a broken toe, was taken off in the 71st minute and Saka’s game ended 10 minutes later.
“It doesn’t look good, because for two players of that importance to tell you they cannot continue in the game, it’s not good news,” said Gunners boss Arteta said.
Rice and Saka both seem likely to miss England’s upcoming matches.
“I don’t know whether to expect them to be fit because if not they don’t come off,” Arteta said.
“What I’m praying for is that after the international break we have the team fully physically equipped, that they are available and that they are fit, because it’s been a nightmare for eight weeks.”