Bukayo Saka has been passed fit to start for Arsenal at the Etihad Stadium, but Gabriel Martinelli is only a substitute.
An injury forced Saka to miss England’s friendlies against Brazil and Belgium but he has been given the green light to play in a massive game for the Gunners in the title race.
Arsenal make one change from their last game, against Porto in the Champions League, with Gabriel Jesus replacing Leandro Trossard up front.
Meanwhile, Kevin de Bruyne is back in the Manchester City starting line-up, replacing Jeremy Doku, and Nathan Ake comes in for the injured Kyle Walker.
Man City: Ortega, Akanji, Dias, Ake, Gvardiol, Rodrigo, Kovacic, De Bruyne, Bernardo, Foden, Haaland.
Subs: Carson, Stones, Grealish, Doku, Alvarez, Gomez, Nunes, Bobb, Lewis.
Arsenal: Raya, White, Saliba, Gabriel, Kiwior, Odegaard, Jorginho, Rice, Saka, Havertz, Jesus.
Subs: Ramsdale, Tomiyasu, Zinchenko, Partey, Smith Rowe, Vieira, Martinelli, Trossard, Nketiah.