Alexis Sanchez starts for Arsenal at Old Trafford.
The Chile striker, who played for his country this week, has been nursing a slight hamstring problem but was assessed ahead of the game and passed fit to lead the Gunners’ attack against Jose Mourinho’s side.
Carl Jenkinson comes in at right-back for the injured Hector Bellerin, while Santi Cazorla remains sidelined with an Achilles problem.
United, meanwhile, make four changes, with Wayne Rooney dropped to the bench.
Antonio Valencia, Ander Herrera, Anthony Martial and Marcus Rashford replace Rooney, Ashley Young, Marouane Fellaini and the suspended Ibrahim Ibrahimovic.
Man Utd: De Gea, Valencia, Jones, Marcos Rojo, Darmian, Carrick, Herrera, Mata, Pogba, Martial, Rashford.
Subs: Romero, Blind, Schneiderlin, Lingard, Young, Memphis, Rooney.
Arsenal: Cech, Jenkinson, Mustafi, Koscielny, Monreal, Coquelin, Elneny, Ramsey, Ozil, Walcott, Alexis.
Subs: Ospina, Gibbs, Gabriel, Xhaka, Iwobi, Oxlade-Chamberlain, Giroud.