Arsenal make three changes for the FA Cup fourth-round clash at the Emirates Stadium.
Ainsley Maitland-Niles replaces the injured Hector Bellerin, while Petr Cech is in goal and Alex Iwobi comes in for Matteo Guendouzi.
United, meanwhile, make five changes, including the recall of former Arsenal man Alexis Sanchez.
Romelu Lukaku, Sergio Romero, Eric Bailly and Luke Shaw are also back for United.
Arsenal: Cech, Maitland-Niles, Sokratis, Koscielny, Kolasinac, Torreira, Xhaka, Iwobi, Ramsey, Aubameyang, Lacazette.
Subs: Leno, Mustafi, Monreal, Lichtsteiner, Elneny, Guendouzi, Ozil.
Man Utd: Romero, Young, Lindelof, Bailly, Shaw, Herrera, Matic, Pogba, Lingard, Lukaku, Sanchez.
Subs: Grant, Dalot, Jones, Fred, Mata, Martial, Rashford.